Recombinant protein products

Name Mouse gp130 / IL6ST / CD130 Protein/重组小鼠 gp130
Specifications 20ug
Serial number CZDB-001
The price Inquiry
Chinese name 重组小鼠 gp130 / IL6ST / CD130 蛋白
Molecular nickname Ac1055, Gp130, Il-6rb
Molecular species Mouse
Express label His,S
Express the host E. coli
Concentration > 95 % as determined by SDS-PAGE
Buffer Lyophilized from sterile PBS, pH 7.4
Storage conditions -70°C,应避免反复冻融。
Basic description Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

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